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The Role of Non-Specific Interactions in Canonical and ALT-Associated PML-Bodies Formation and Dynamics
In this work, we put forward a hypothesis about the decisive role of multivalent nonspecific interactions in the early stages of PML body formation. Our analysis of the PML isoform sequences showed that some of the PML isoforms, primarily PML-II, are prone to phase separation due to their polyamphol...
Autores principales: | Fonin, Alexander V., Silonov, Sergey A., Shpironok, Olesya G., Antifeeva, Iuliia A., Petukhov, Alexey V., Romanovich, Anna E., Kuznetsova, Irina M., Uversky, Vladimir N., Turoverov, Konstantin K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198325/ https://www.ncbi.nlm.nih.gov/pubmed/34072343 http://dx.doi.org/10.3390/ijms22115821 |
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