S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3

Background: Reduction of the Sphingosine-1-phosphate (S1P) degrading enzyme S1P lyase 1 (SGPL1) initiates colorectal cancer progression with parallel loss of colon function in mice. We aimed to investigate the effect of SGPL1 knockout on the stem cell niche in these mice. Methods: We performed immun...

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Detalles Bibliográficos
Autores principales: Schwiebs, Anja, Faqar-Uz-Zaman, Farha, Herrero San Juan, Martina, Radeke, Heinfried H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198365/
https://www.ncbi.nlm.nih.gov/pubmed/34073605
http://dx.doi.org/10.3390/ijms22115682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198365/
https://www.ncbi.nlm.nih.gov/pubmed/34073605
http://dx.doi.org/10.3390/ijms22115682

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