Breast Cancer Predisposition Genes and Synthetic Lethality

BRCA1 and BRCA2 are tumor suppressor genes with pivotal roles in the development of breast and ovarian cancers. These genes are essential for DNA double-strand break repair via homologous recombination (HR), which is a virtually error-free DNA repair mechanism. Following BRCA1 or BRCA2 mutations, HR...

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Detalles Bibliográficos
Autores principales: Neiger, Hannah E., Siegler, Emily L., Shi, Yihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198377/
https://www.ncbi.nlm.nih.gov/pubmed/34070674
http://dx.doi.org/10.3390/ijms22115614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198377/
https://www.ncbi.nlm.nih.gov/pubmed/34070674
http://dx.doi.org/10.3390/ijms22115614

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