Solid-Phase Synthesis of an Insect Pyrokinin Analog Incorporating an Imidazoline Ring as Isosteric Replacement of a trans Peptide Bond

A facile solid-phase synthetic method for incorporating the imidazoline ring motif, a surrogate for a trans peptide bond, into bioactive peptides is reported. The example described is the synthesis of an imidazoline peptidomimetic analog of an insect pyrokinin neuropeptide via a cyclization reaction...

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Detalles Bibliográficos
Autores principales: Kaczmarek, Krzysztof, Pacholczyk-Sienicka, Barbara, Albrecht, Łukasz, Zabrocki, Janusz, Nachman, Ronald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198379/
https://www.ncbi.nlm.nih.gov/pubmed/34071640
http://dx.doi.org/10.3390/molecules26113271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198379/
https://www.ncbi.nlm.nih.gov/pubmed/34071640
http://dx.doi.org/10.3390/molecules26113271

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