A Novel Formulation of Cisplatin with γ-Polyglutamic Acid and Chitosan Reduces Its Adverse Renal Effects: An In Vitro and In Vivo Animal Study

Cisplatin (cis-diamminedichloroplatinum (II); CDDP) is a key chemotherapeutic agent but causes renal damage and other off-target effects. Here, we describe the pharmacological and biochemical characteristics of a novel formulation of CDDP complexed with γ-polyglutamic acid (γ-PGA) and chitosan (CS),...

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Detalles Bibliográficos
Autores principales: Sasai, Masao, Sakura, Kazuma, Matsuda, Takayuki, Uyama, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198433/
https://www.ncbi.nlm.nih.gov/pubmed/34070811
http://dx.doi.org/10.3390/polym13111803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198433/
https://www.ncbi.nlm.nih.gov/pubmed/34070811
http://dx.doi.org/10.3390/polym13111803

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