Cargando…

Curcumin-Loaded Nanoparticles Impair the Pro-Tumor Activity of Acid-Stressed MSC in an In Vitro Model of Osteosarcoma

In the tumor microenvironment, mesenchymal stromal cells (MSCs) are key modulators of cancer cell behavior in response to several stimuli. Intratumoral acidosis is a metabolic trait of fast-growing tumors that can induce a pro-tumorigenic phenotype in MSCs through the activation of the NF-κB-mediate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Pompo, Gemma, Cortini, Margherita, Palomba, Roberto, Di Francesco, Valentina, Bellotti, Elena, Decuzzi, Paolo, Baldini, Nicola, Avnet, Sofia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198446/ https://www.ncbi.nlm.nih.gov/pubmed/34071200 http://dx.doi.org/10.3390/ijms22115760

Ejemplares similares

Acid Microenvironment in Bone Sarcomas
por: Di Pompo, Gemma, et al.
Publicado: (2021)

Pre-clinical Models for Studying the Interaction Between Mesenchymal Stromal Cells and Cancer Cells and the Induction of Stemness
por: Avnet, Sofia, et al.
Publicado: (2019)

Exploring Metabolic Adaptations to the Acidic Microenvironment of Osteosarcoma Cells Unveils Sphingosine 1-Phosphate as a Valuable Therapeutic Target
por: Cortini, Margherita, et al.
Publicado: (2021)

Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion
por: Cortini, Margherita, et al.
Publicado: (2016)

Cause and effect of microenvironmental acidosis on bone metastases
por: Avnet, Sofia, et al.
Publicado: (2019)

New Advances in the Study of Bone Tumors: A Lesson From the 3D Environment
por: Cortini, Margherita, et al.
Publicado: (2019)

3D Printing and Bioprinting to Model Bone Cancer: The Role of Materials and Nanoscale Cues in Directing Cell Behavior
por: Fischetti, Tiziana, et al.
Publicado: (2021)

Contribution of Mitochondrial Activity to Doxorubicin-Resistance in Osteosarcoma Cells
por: Giacomini, Isabella, et al.
Publicado: (2023)

Epigenetic Regulation Mediated by Sphingolipids in Cancer
por: Bozzini, Nicolò, et al.
Publicado: (2023)

Radiodynamic Therapy with Acridine Orange Is an Effective Treatment for Bone Metastases
por: Di Pompo, Gemma, et al.
Publicado: (2022)

Endogenous Extracellular Matrix Regulates the Response of Osteosarcoma 3D Spheroids to Doxorubicin
por: Cortini, Margherita, et al.
Publicado: (2023)

The Release of Inflammatory Mediators from Acid-Stimulated Mesenchymal Stromal Cells Favours Tumour Invasiveness and Metastasis in Osteosarcoma
por: Avnet, Sofia, et al.
Publicado: (2021)

Unravelling the Effect of Citrate on the Features and Biocompatibility of Magnesium Phosphate-Based Bone Cements
por: Gelli, Rita, et al.
Publicado: (2020)

Acid-Induced Inflammatory Cytokines in Osteoblasts: A Guided Path to Osteolysis in Bone Metastasis
por: Di Pompo, Gemma, et al.
Publicado: (2021)

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance
por: Avnet, Sofia, et al.
Publicado: (2016)

Ameliorating Amyloid-β Fibrils Triggered Inflammation via Curcumin-Loaded Polymeric Nanoconstructs
por: Ameruoso, Andrea, et al.
Publicado: (2017)

Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes
por: Di Francesco, Valentina, et al.
Publicado: (2023)

Synthesis of Two Methotrexate Prodrugs for Optimizing Drug Loading into Liposomes
por: Di Francesco, Valentina, et al.
Publicado: (2021)

Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma
por: Di Pompo, Gemma, et al.
Publicado: (2017)

FT-IR Spectral Signature of Sensitive and Multidrug-Resistant Osteosarcoma Cell-Derived Extracellular Nanovesicles
por: Perut, Francesca, et al.
Publicado: (2022)

Behavioral Voluntary and Social Bioassays Enabling Identification of Complex and Sex-Dependent Pain-(-Related) Phenotypes in Rats with Bone Cancer
por: Segelcke, Daniel, et al.
Publicado: (2023)

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells
por: Bonuccelli, Gloria, et al.
Publicado: (2014)

The Effects of Systemic and Local Acidosis on Insulin Resistance and Signaling
por: Baldini, Nicola, et al.
Publicado: (2018)

Potassium citrate prevents increased osteoclastogenesis resulting from acidic conditions: Implication for the treatment of postmenopausal bone loss
por: Granchi, Donatella, et al.
Publicado: (2017)

Impairment of Lysosomal Activity as a Therapeutic Modality Targeting Cancer Stem Cells of Embryonal Rhabdomyosarcoma Cell Line RD
por: Salerno, Manuela, et al.
Publicado: (2014)

Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients’ bed
por: Ferrari, Stefano, et al.
Publicado: (2013)

Long-lasting rescue of schizophrenia-relevant cognitive impairments via risperidone-loaded microPlates
por: Bellotti, Elena, et al.
Publicado: (2022)

The Microfluidic Trainer: Design, Fabrication and Validation of a Tool for Testing and Improving Manual Skills
por: Costa, Francesco, et al.
Publicado: (2020)

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype
por: Waterman, Ruth S., et al.
Publicado: (2010)

Insulin Granule-Loaded MicroPlates for Modulating Blood Glucose Levels in Type-1 Diabetes
por: Primavera, Rosita, et al.
Publicado: (2021)

Perfused Platforms to Mimic Bone Microenvironment at the Macro/Milli/Microscale: Pros and Cons
por: Lipreri, Maria Veronica, et al.
Publicado: (2022)

Identification and Validation of Housekeeping Genes for Gene Expression Analysis of Cancer Stem Cells
por: Lemma, Silvia, et al.
Publicado: (2016)

Prominent role of RAB39A-RXRB axis in cancer development and stemness
por: Chano, Tokuhiro, et al.
Publicado: (2018)

Validation of Suitable Housekeeping Genes for the Normalization of mRNA Expression for Studying Tumor Acidosis
por: Lemma, Silvia, et al.
Publicado: (2018)

Dual targeting curcumin loaded alendronate-hyaluronan- octadecanoic acid micelles for improving osteosarcoma therapy
por: Xi, Yanhai, et al.
Publicado: (2019)

Cytotoxic effects of curcumin in osteosarcoma cells
por: Moran, JM, et al.
Publicado: (2014)

Modulating the vascular behavior of metastatic breast cancer cells by curcumin treatment
por: Palange, Anna L., et al.
Publicado: (2012)

Psychostimulants Modafinil, Atomoxetine and Guanfacine Impair Bone Cell Differentiation and MSC Migration
por: Wagener, Nele, et al.
Publicado: (2022)

Correction: Shape-specific microfabricated particles for biomedical applications: a review
por: Moore, Thomas L., et al.
Publicado: (2022)

Shape-specific microfabricated particles for biomedical applications: a review
por: Moore, Thomas L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_f8o24o6ksefckv0s6b86cljiff