Nuclear Respiratory Factor-1, a Novel SMAD4 Binding Protein, Represses TGF-β/SMAD4 Signaling by Functioning as a Transcriptional Cofactor

SMAD4, a key regulator of transforming growth factor-β (TGF-β) signaling, plays a major role in cell growth, migration, and apoptosis. In particular, TGF-β/SMAD induces growth arrest, and SMAD4 induces the expression of target genes such as p21WAF1 and p15INK4b through its interaction with several c...

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Detalles Bibliográficos
Autores principales: Rajasekaran, Nirmal, Song, Kyoung, Lee, Jin-Hee, Wei, Yun, Erkin, Özgür Cem, Lee, Hunseok, Shin, Young-Kee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198518/
https://www.ncbi.nlm.nih.gov/pubmed/34070531
http://dx.doi.org/10.3390/ijms22115595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198518/
https://www.ncbi.nlm.nih.gov/pubmed/34070531
http://dx.doi.org/10.3390/ijms22115595

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