NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth

SIMPLE SUMMARY: Bis-indole derived (CDIMs) bind the orphan nuclear receptor 4A1 (NR4A1) and inhibit NR4A1-regulated cancer cell and tumor growth. In this study a subset of 3,5-disubstituted phenyl CDIM compounds that bound NR4A1 were investigated in a breast cancer model. All of these analogs were p...

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Detalles Bibliográficos
Autores principales: Karki, Keshav, Mohankumar, Kumaravel, Schoeller, Abigail, Martin, Gregory, Shrestha, Rupesh, Safe, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198788/
https://www.ncbi.nlm.nih.gov/pubmed/34072371
http://dx.doi.org/10.3390/cancers13112682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198788/
https://www.ncbi.nlm.nih.gov/pubmed/34072371
http://dx.doi.org/10.3390/cancers13112682

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