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NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth

SIMPLE SUMMARY: Bis-indole derived (CDIMs) bind the orphan nuclear receptor 4A1 (NR4A1) and inhibit NR4A1-regulated cancer cell and tumor growth. In this study a subset of 3,5-disubstituted phenyl CDIM compounds that bound NR4A1 were investigated in a breast cancer model. All of these analogs were p...

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Detalles Bibliográficos
Autores principales:	Karki, Keshav, Mohankumar, Kumaravel, Schoeller, Abigail, Martin, Gregory, Shrestha, Rupesh, Safe, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198788/ https://www.ncbi.nlm.nih.gov/pubmed/34072371 http://dx.doi.org/10.3390/cancers13112682

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