CX-5461 Enhances the Efficacy of APR-246 via Induction of DNA Damage and Replication Stress in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking targeted therapy. Here, we evaluated the anti-cancer activity of APR-246, a P53 activator, and CX-5461, a RNA polymerase I inhibitor, in the treatment of TNBC cells. We tested the efficacy of individual and combin...

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Detalles Bibliográficos
Autores principales: Makhale, Ashwini, Nanayakkara, Devathri, Raninga, Prahlad, Khanna, Kum Kum, Kalimutho, Murugan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198831/
https://www.ncbi.nlm.nih.gov/pubmed/34071360
http://dx.doi.org/10.3390/ijms22115782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198831/
https://www.ncbi.nlm.nih.gov/pubmed/34071360
http://dx.doi.org/10.3390/ijms22115782

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