Mechanisms of Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers

SIMPLE SUMMARY: A subset of colorectal cancers (CRCs) is characterized by a mismatch repair deficiency that is frequently associated with microsatellite instability (MSI). The compromised DNA repair machinery leads to the accumulation of tumor neoantigens affecting the sensitivity of MSI metastatic...

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Detalles Bibliográficos
Autores principales: Amodio, Vito, Mauri, Gianluca, Reilly, Nicole M., Sartore-Bianchi, Andrea, Siena, Salvatore, Bardelli, Alberto, Germano, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199207/
https://www.ncbi.nlm.nih.gov/pubmed/34072037
http://dx.doi.org/10.3390/cancers13112638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199207/
https://www.ncbi.nlm.nih.gov/pubmed/34072037
http://dx.doi.org/10.3390/cancers13112638

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