Cargando…
Pharmacophore-Based Virtual Screening of Novel Competitive Inhibitors of the Neurodegenerative Disease Target Kynurenine-3-Monooxygenase
The pathogenesis of several neurodegenerative diseases such as Alzheimer’s or Huntington’s disease has been associated with metabolic dysfunctions caused by imbalances in the brain and cerebral spinal fluid levels of neuroactive metabolites. Kynurenine monooxygenase (KMO) is considered an ideal ther...
Autores principales: | Gotina, Lizaveta, Seo, Seon Hee, Kim, Chae Won, Lim, Sang Min, Pae, Ae Nim |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199213/ https://www.ncbi.nlm.nih.gov/pubmed/34073016 http://dx.doi.org/10.3390/molecules26113314 |
Ejemplares similares
-
Molecular Characterization of Hepatitis C Virus for Developed Antiviral Agents Resistance Mutations and New Insights into in-silico Prediction Studies
por: El-Sokkary, Mohamed M Adel, et al.
Publicado: (2020) -
Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress
por: Elsherbeny, Mohamed H., et al.
Publicado: (2021) -
The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
por: Hughes, Tamera D., et al.
Publicado: (2022) -
Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition
por: Phillips, Robert S., et al.
Publicado: (2019) -
Structural basis of kynurenine 3-monooxygenase inhibition
por: Amaral, Marta, et al.
Publicado: (2013)