Size- and Surface- Dual Engineered Small Polyplexes for Efficiently Targeting Delivery of siRNA

Though siRNA-based therapy has achieved great progress, efficient siRNA delivery remains a challenge. Here, we synthesized a copolymer PAsp(-N=C-PEG)-PCys-PAsp(DETA) consisting of a poly(aspartate) block grafted with comb-like PEG side chains via a pH-sensitive imine bond (PAsp(-N=C-PEG) block), a p...

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Detalles Bibliográficos
Autores principales: Liu, Shuang, Deng, Shaohui, Li, Xiaoxia, Cheng, Du
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199253/
https://www.ncbi.nlm.nih.gov/pubmed/34072265
http://dx.doi.org/10.3390/molecules26113238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199253/
https://www.ncbi.nlm.nih.gov/pubmed/34072265
http://dx.doi.org/10.3390/molecules26113238

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