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Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications
Intrinsic disorder is a natural feature of polypeptide chains, resulting in the lack of a defined three-dimensional structure. Conformational changes in intrinsically disordered regions of a protein lead to unstable β-sheet enriched intermediates, which are stabilized by intermolecular interactions...
Autores principales: | Candelise, Niccolò, Scaricamazza, Silvia, Salvatori, Illari, Ferri, Alberto, Valle, Cristiana, Manganelli, Valeria, Garofalo, Tina, Sorice, Maurizio, Misasi, Roberta |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199687/ https://www.ncbi.nlm.nih.gov/pubmed/34199513 http://dx.doi.org/10.3390/ijms22116016 |
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