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Skin insertion site culture for the prediction of primary bloodstream infection

PURPOSE: Previous studies have analyzed the capability of skin insertion site culture to predict catheter-related bloodstream infection (CRBSI). However, there has been not analyzed its capability to predict primary bloodstream infection (PBSI), that include CRBSI and bloodstream infection of unknow...

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Autores principales: Lorente, Leonardo, Lecuona, María, Pérez-Llombet, Alejandra, González-Mesa, Adriana, Callejon, Manuel, Jiménez, Alejandro, Mora, María Luisa, Madueño, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200300/
https://www.ncbi.nlm.nih.gov/pubmed/34121133
http://dx.doi.org/10.1007/s11845-021-02685-1
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author Lorente, Leonardo
Lecuona, María
Pérez-Llombet, Alejandra
González-Mesa, Adriana
Callejon, Manuel
Jiménez, Alejandro
Mora, María Luisa
Madueño, Ana
author_facet Lorente, Leonardo
Lecuona, María
Pérez-Llombet, Alejandra
González-Mesa, Adriana
Callejon, Manuel
Jiménez, Alejandro
Mora, María Luisa
Madueño, Ana
author_sort Lorente, Leonardo
collection PubMed
description PURPOSE: Previous studies have analyzed the capability of skin insertion site culture to predict catheter-related bloodstream infection (CRBSI). However, there has been not analyzed its capability to predict primary bloodstream infection (PBSI), that include CRBSI and bloodstream infection of unknown origin (BSIUO). The novel objective of our study was to determine the capability of insertion skin site culture to predict CRBSI and primary bloodstream infection (PBSI), that include CRBSI and bloodstream infection of unknown origin (BSIUO). MATERIAL AND METHODS: Observational and prospective study in one Intensive Care Unit. Patients with some central venous catheter (CVC) at least during 7 days and suspected catheter-related infection (CRI) (new episode of fever or sepsis) were included. Cultures of insertion skin site, paired blood samples, catheter-tip, and other clinical samples were taken. Capability of insertion skin site culture to predict CRBSI and PBSI was determined. RESULTS: We included 108 CVC from 96 CRI suspicion episodes. The causes that motivated CRI suspicion were 20 (18.5%) PBSI, 44 (40.7%) other infections, and 44 (40.7%) unknown. Among the 20 PBSI, 11 (55%) were CRBSI and 9 (45%) were BSIUO. Negative predictive value of insertion skin site culture to predict CRBSI was 95% (87–98%) and to predict PBSI was 85% (76–91%). CONCLUSIONS: The new finding of our study was that skin insertion site culture had a good negative predicted valued for the prediction of CRBSI and PBSI.
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spelling pubmed-82003002021-06-15 Skin insertion site culture for the prediction of primary bloodstream infection Lorente, Leonardo Lecuona, María Pérez-Llombet, Alejandra González-Mesa, Adriana Callejon, Manuel Jiménez, Alejandro Mora, María Luisa Madueño, Ana Ir J Med Sci Original Article PURPOSE: Previous studies have analyzed the capability of skin insertion site culture to predict catheter-related bloodstream infection (CRBSI). However, there has been not analyzed its capability to predict primary bloodstream infection (PBSI), that include CRBSI and bloodstream infection of unknown origin (BSIUO). The novel objective of our study was to determine the capability of insertion skin site culture to predict CRBSI and primary bloodstream infection (PBSI), that include CRBSI and bloodstream infection of unknown origin (BSIUO). MATERIAL AND METHODS: Observational and prospective study in one Intensive Care Unit. Patients with some central venous catheter (CVC) at least during 7 days and suspected catheter-related infection (CRI) (new episode of fever or sepsis) were included. Cultures of insertion skin site, paired blood samples, catheter-tip, and other clinical samples were taken. Capability of insertion skin site culture to predict CRBSI and PBSI was determined. RESULTS: We included 108 CVC from 96 CRI suspicion episodes. The causes that motivated CRI suspicion were 20 (18.5%) PBSI, 44 (40.7%) other infections, and 44 (40.7%) unknown. Among the 20 PBSI, 11 (55%) were CRBSI and 9 (45%) were BSIUO. Negative predictive value of insertion skin site culture to predict CRBSI was 95% (87–98%) and to predict PBSI was 85% (76–91%). CONCLUSIONS: The new finding of our study was that skin insertion site culture had a good negative predicted valued for the prediction of CRBSI and PBSI. Springer International Publishing 2021-06-14 2022 /pmc/articles/PMC8200300/ /pubmed/34121133 http://dx.doi.org/10.1007/s11845-021-02685-1 Text en © Royal Academy of Medicine in Ireland 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Lorente, Leonardo
Lecuona, María
Pérez-Llombet, Alejandra
González-Mesa, Adriana
Callejon, Manuel
Jiménez, Alejandro
Mora, María Luisa
Madueño, Ana
Skin insertion site culture for the prediction of primary bloodstream infection
title Skin insertion site culture for the prediction of primary bloodstream infection
title_full Skin insertion site culture for the prediction of primary bloodstream infection
title_fullStr Skin insertion site culture for the prediction of primary bloodstream infection
title_full_unstemmed Skin insertion site culture for the prediction of primary bloodstream infection
title_short Skin insertion site culture for the prediction of primary bloodstream infection
title_sort skin insertion site culture for the prediction of primary bloodstream infection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200300/
https://www.ncbi.nlm.nih.gov/pubmed/34121133
http://dx.doi.org/10.1007/s11845-021-02685-1
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