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Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions
A mathematical model describing the dynamics of Corona virus disease 2019 (COVID-19) is constructed and studied. The model assessed the role of denial on the spread of the pandemic in the world. Dynamic stability analyzes show that the equilibria, disease-free equilibrium (DFE) and endemic equilibri...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier B.V. on behalf of African Institute of Mathematical Sciences / Next Einstein Initiative.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200329/ https://www.ncbi.nlm.nih.gov/pubmed/34151051 http://dx.doi.org/10.1016/j.sciaf.2021.e00811 |
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author | Gweryina, Reuben Iortyer Madubueze, Chinwendu Emilian Kaduna, Francis Shienbee |
author_facet | Gweryina, Reuben Iortyer Madubueze, Chinwendu Emilian Kaduna, Francis Shienbee |
author_sort | Gweryina, Reuben Iortyer |
collection | PubMed |
description | A mathematical model describing the dynamics of Corona virus disease 2019 (COVID-19) is constructed and studied. The model assessed the role of denial on the spread of the pandemic in the world. Dynamic stability analyzes show that the equilibria, disease-free equilibrium (DFE) and endemic equilibrium point (EEP) of the model are globally asymptotically stable for [Formula: see text] and [Formula: see text] , respectively. Again, the model is shown via numerical simulations to possess the backward bifurcation, where a stable DFE co-exists with one or more stable endemic equilibria when the control reproduction number, [Formula: see text] is less than unity and the rate of denial of COVID-19 is above its upper bound. We then apply the optimal control strategy for controlling the spread of the disease using the controllable variables such as COVID-19 prevention, hospitalization and maximum treatment efforts. Using the Pontryagin maximum principle, we derive analytically the optimal controls of the model. The aforementioned control strategies are performed numerically in the presence of denial and without denial rate. Among such experiments, results without denial have shown to be more productive in ending the pandemic than others where the denial of the disease invalidates the effectiveness of the controls causing the disease to continue ravaging the globe. |
format | Online Article Text |
id | pubmed-8200329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Author(s). Published by Elsevier B.V. on behalf of African Institute of Mathematical Sciences / Next Einstein Initiative. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82003292021-06-15 Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions Gweryina, Reuben Iortyer Madubueze, Chinwendu Emilian Kaduna, Francis Shienbee Sci Afr Article A mathematical model describing the dynamics of Corona virus disease 2019 (COVID-19) is constructed and studied. The model assessed the role of denial on the spread of the pandemic in the world. Dynamic stability analyzes show that the equilibria, disease-free equilibrium (DFE) and endemic equilibrium point (EEP) of the model are globally asymptotically stable for [Formula: see text] and [Formula: see text] , respectively. Again, the model is shown via numerical simulations to possess the backward bifurcation, where a stable DFE co-exists with one or more stable endemic equilibria when the control reproduction number, [Formula: see text] is less than unity and the rate of denial of COVID-19 is above its upper bound. We then apply the optimal control strategy for controlling the spread of the disease using the controllable variables such as COVID-19 prevention, hospitalization and maximum treatment efforts. Using the Pontryagin maximum principle, we derive analytically the optimal controls of the model. The aforementioned control strategies are performed numerically in the presence of denial and without denial rate. Among such experiments, results without denial have shown to be more productive in ending the pandemic than others where the denial of the disease invalidates the effectiveness of the controls causing the disease to continue ravaging the globe. The Author(s). Published by Elsevier B.V. on behalf of African Institute of Mathematical Sciences / Next Einstein Initiative. 2021-07 2021-06-14 /pmc/articles/PMC8200329/ /pubmed/34151051 http://dx.doi.org/10.1016/j.sciaf.2021.e00811 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Gweryina, Reuben Iortyer Madubueze, Chinwendu Emilian Kaduna, Francis Shienbee Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions |
title | Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions |
title_full | Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions |
title_fullStr | Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions |
title_full_unstemmed | Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions |
title_short | Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions |
title_sort | mathematical assessment of the role of denial on covid-19 transmission with non-linear incidence and treatment functions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200329/ https://www.ncbi.nlm.nih.gov/pubmed/34151051 http://dx.doi.org/10.1016/j.sciaf.2021.e00811 |
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