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Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions

A mathematical model describing the dynamics of Corona virus disease 2019 (COVID-19) is constructed and studied. The model assessed the role of denial on the spread of the pandemic in the world. Dynamic stability analyzes show that the equilibria, disease-free equilibrium (DFE) and endemic equilibri...

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Autores principales: Gweryina, Reuben Iortyer, Madubueze, Chinwendu Emilian, Kaduna, Francis Shienbee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. on behalf of African Institute of Mathematical Sciences / Next Einstein Initiative. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200329/
https://www.ncbi.nlm.nih.gov/pubmed/34151051
http://dx.doi.org/10.1016/j.sciaf.2021.e00811
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author Gweryina, Reuben Iortyer
Madubueze, Chinwendu Emilian
Kaduna, Francis Shienbee
author_facet Gweryina, Reuben Iortyer
Madubueze, Chinwendu Emilian
Kaduna, Francis Shienbee
author_sort Gweryina, Reuben Iortyer
collection PubMed
description A mathematical model describing the dynamics of Corona virus disease 2019 (COVID-19) is constructed and studied. The model assessed the role of denial on the spread of the pandemic in the world. Dynamic stability analyzes show that the equilibria, disease-free equilibrium (DFE) and endemic equilibrium point (EEP) of the model are globally asymptotically stable for [Formula: see text] and [Formula: see text] , respectively. Again, the model is shown via numerical simulations to possess the backward bifurcation, where a stable DFE co-exists with one or more stable endemic equilibria when the control reproduction number, [Formula: see text] is less than unity and the rate of denial of COVID-19 is above its upper bound. We then apply the optimal control strategy for controlling the spread of the disease using the controllable variables such as COVID-19 prevention, hospitalization and maximum treatment efforts. Using the Pontryagin maximum principle, we derive analytically the optimal controls of the model. The aforementioned control strategies are performed numerically in the presence of denial and without denial rate. Among such experiments, results without denial have shown to be more productive in ending the pandemic than others where the denial of the disease invalidates the effectiveness of the controls causing the disease to continue ravaging the globe.
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spelling pubmed-82003292021-06-15 Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions Gweryina, Reuben Iortyer Madubueze, Chinwendu Emilian Kaduna, Francis Shienbee Sci Afr Article A mathematical model describing the dynamics of Corona virus disease 2019 (COVID-19) is constructed and studied. The model assessed the role of denial on the spread of the pandemic in the world. Dynamic stability analyzes show that the equilibria, disease-free equilibrium (DFE) and endemic equilibrium point (EEP) of the model are globally asymptotically stable for [Formula: see text] and [Formula: see text] , respectively. Again, the model is shown via numerical simulations to possess the backward bifurcation, where a stable DFE co-exists with one or more stable endemic equilibria when the control reproduction number, [Formula: see text] is less than unity and the rate of denial of COVID-19 is above its upper bound. We then apply the optimal control strategy for controlling the spread of the disease using the controllable variables such as COVID-19 prevention, hospitalization and maximum treatment efforts. Using the Pontryagin maximum principle, we derive analytically the optimal controls of the model. The aforementioned control strategies are performed numerically in the presence of denial and without denial rate. Among such experiments, results without denial have shown to be more productive in ending the pandemic than others where the denial of the disease invalidates the effectiveness of the controls causing the disease to continue ravaging the globe. The Author(s). Published by Elsevier B.V. on behalf of African Institute of Mathematical Sciences / Next Einstein Initiative. 2021-07 2021-06-14 /pmc/articles/PMC8200329/ /pubmed/34151051 http://dx.doi.org/10.1016/j.sciaf.2021.e00811 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gweryina, Reuben Iortyer
Madubueze, Chinwendu Emilian
Kaduna, Francis Shienbee
Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions
title Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions
title_full Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions
title_fullStr Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions
title_full_unstemmed Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions
title_short Mathematical assessment of the role of denial on COVID-19 transmission with non-linear incidence and treatment functions
title_sort mathematical assessment of the role of denial on covid-19 transmission with non-linear incidence and treatment functions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200329/
https://www.ncbi.nlm.nih.gov/pubmed/34151051
http://dx.doi.org/10.1016/j.sciaf.2021.e00811
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