Deciphering in silico the Role of Mutated Na(V)1.1 Sodium Channels in Enhancing Trigeminal Nociception in Familial Hemiplegic Migraine Type 3

Familial hemiplegic migraine type 3 (FHM3) is caused by gain-of-function mutations in the SCN1A gene that encodes the α1 subunit of voltage-gated Na(V)1.1 sodium channels. The high level of expression of Na(V)1.1 channels in peripheral trigeminal neurons may lead to abnormal nociceptive signaling th...

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Detalles Bibliográficos
Autores principales: Suleimanova, Alina, Talanov, Max, van den Maagdenberg, Arn M. J. M., Giniatullin, Rashid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200561/
https://www.ncbi.nlm.nih.gov/pubmed/34135733
http://dx.doi.org/10.3389/fncel.2021.644047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200561/
https://www.ncbi.nlm.nih.gov/pubmed/34135733
http://dx.doi.org/10.3389/fncel.2021.644047

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