Effect of CpG Depletion of Vector Genome on CD8(+) T Cell Responses in AAV Gene Therapy

Adeno associated viral (AAV) vectors have emerged as a preferred platform for in vivo gene replacement therapy and represent one of the most promising strategies to treat monogenetic disorders such as hemophilia. However, immune responses to gene transfer have hampered human gene therapy in clinical...

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Detalles Bibliográficos
Autores principales: Bertolini, Thais B., Shirley, Jamie L., Zolotukhin, Irene, Li, Xin, Kaisho, Tsuneyasu, Xiao, Weidong, Kumar, Sandeep R. P., Herzog, Roland W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200677/
https://www.ncbi.nlm.nih.gov/pubmed/34135899
http://dx.doi.org/10.3389/fimmu.2021.672449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200677/
https://www.ncbi.nlm.nih.gov/pubmed/34135899
http://dx.doi.org/10.3389/fimmu.2021.672449

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