Impact of Crystal Habit on the Dissolution Rate and In Vivo Pharmacokinetics of Sorafenib Tosylate

The dissolution rate is the rate-limiting step for Biopharmaceutics Classification System (BCS) class II drugs to enhance their in vivo pharmacokinetic behaviors. There are some factors affecting the dissolution rate, such as polymorphism, particle size, and crystal habit. In this study, to improve...

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Detalles Bibliográficos
Autores principales: Phan, Chi Uyen, Shen, Jie, Yu, Kaxi, Mao, Jianming, Tang, Guping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201088/
https://www.ncbi.nlm.nih.gov/pubmed/34200376
http://dx.doi.org/10.3390/molecules26113469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201088/
https://www.ncbi.nlm.nih.gov/pubmed/34200376
http://dx.doi.org/10.3390/molecules26113469

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