Systematic Review of Pharmacogenetic Factors That Influence High-Dose Methotrexate Pharmacokinetics in Pediatric Malignancies

SIMPLE SUMMARY: High-dose methotrexate is commonly used to treat several types of cancer. While effective, elimination of high-dose methotrexate from the body is highly variable and delayed elimination can lead to serious and sometime life-threatening adverse events. There have been many clinical st...

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Detalles Bibliográficos
Autores principales: Taylor, Zachary L., Vang, Jesper, Lopez-Lopez, Elixabet, Oosterom, Natanja, Mikkelsen, Torben, Ramsey, Laura B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201112/
https://www.ncbi.nlm.nih.gov/pubmed/34200242
http://dx.doi.org/10.3390/cancers13112837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201112/
https://www.ncbi.nlm.nih.gov/pubmed/34200242
http://dx.doi.org/10.3390/cancers13112837

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