Cargando…

Topical Astodrimer Sodium, a Non-Toxic Polyanionic Dendrimer, Demonstrates Antiviral Activity in an Experimental Ocular Adenovirus Infection Model

There is no approved antiviral therapy for adenovirus (HAdV) ocular infections. Astodrimer sodium (SPL7013) is a polyanionic dendrimer with antiviral activity. The current study evaluated the ocular tolerability and anti-adenoviral efficacy of topical SPL7013 in rabbit ocular models. In a tolerabili...

Descripción completa

Detalles Bibliográficos
Autores principales:	Romanowski, Eric G., Yates, Kathleen A., Paull, Jeremy R. A., Heery, Graham P., Shanks, Robert M. Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201124/ https://www.ncbi.nlm.nih.gov/pubmed/34198721 http://dx.doi.org/10.3390/molecules26113419

Ejemplares similares

Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro
por: Paull, Jeremy R.A., et al.
Publicado: (2021)

Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial
por: Castellarnau, Alex, et al.
Publicado: (2022)

The in vitro Evaluation of the Activity of COVID-19 Antiviral Drugs Against Adenovirus
por: Romanowski, Eric G, et al.
Publicado: (2021)

Antiviral mechanism of polyanionic carbosilane dendrimers against HIV-1
por: Vacas-Córdoba, Enrique, et al.
Publicado: (2016)

Filociclovir Is an Active Antiviral Agent against Ocular Adenovirus Isolates In Vitro and in the Ad5/NZW Rabbit Ocular Model
por: Romanowski, Eric G., et al.
Publicado: (2021)

Ranpirnase (OKG-0301), a Novel Ribonuclease, Demonstrates Antiviral Activity against Adenovirus in the Ad5/NZW Rabbit Ocular Replication Model
por: Romanowski, Eric G., et al.
Publicado: (2022)

Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 Mice
por: Paull, Jeremy R. A., et al.
Publicado: (2021)

Astodrimer sodium and bacterial vaginosis: a mini review
por: Mendling, Werner, et al.
Publicado: (2022)

Nanotechnology against human cytomegalovirus in vitro: polyanionic carbosilane dendrimers as antiviral agents
por: Relaño-Rodríguez, I., et al.
Publicado: (2021)

Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen
por: Ceña-Diez, Rafael, et al.
Publicado: (2016)

A Fast and Convenient Synthesis of New Water-Soluble, Polyanionic Dendrimers
por: Salamończyk, Grzegorz M.
Publicado: (2021)

A phase 3, randomized, controlled trial of Astodrimer 1% Gel for preventing recurrent bacterial vaginosis
por: Schwebke, Jane R., et al.
Publicado: (2021)

Cyclopentenylcytosine (CPE-C): In Vitro and In Vivo Evaluation as an Antiviral against Adenoviral Ocular Infections
por: Romanowski, Eric G., et al.
Publicado: (2023)

Polyanionic carbosilane dendrimers as a new adjuvant in combination with latency reversal agents for HIV treatment
por: Relaño-Rodríguez, Ignacio, et al.
Publicado: (2019)

Safety of G2-S16 Polyanionic Carbosilane Dendrimer as Possible HIV-1 Vaginal Microbicide
por: Martin-Moreno, Alba, et al.
Publicado: (2022)

Cefiderocol is an effective topical monotherapy for experimental extensively-drug resistant Pseudomonas aeruginosa keratitis
por: Romanowski, Eric G., et al.
Publicado: (2023)

Polyanion‐Type Electrode Materials for Sodium‐Ion Batteries
por: Ni, Qiao, et al.
Publicado: (2017)

A phase 2, double-blind, multicenter, randomized, placebo-controlled, dose‑ranging study of the efficacy and safety of Astodrimer Gel for the treatment of bacterial vaginosis
por: Waldbaum, Arthur S., et al.
Publicado: (2020)

Role of G2-S16 Polyanionic Carbosilane Dendrimer in the Prevention of Respiratory Syncytial Virus Infection In Vitro and In Vivo in Mice
por: Rodriguez-Izquierdo, Ignacio, et al.
Publicado: (2021)

Predatory bacteria are nontoxic to the rabbit ocular surface
por: Romanowski, Eric G., et al.
Publicado: (2016)

Speciation and Antibiotic Susceptibilities of Coagulase Negative Staphylococci Isolated from Ocular Infections
por: Romanowski, John E., et al.
Publicado: (2021)

Structure Activity Relationship of Dendrimer Microbicides with Dual Action Antiviral Activity
por: Tyssen, David, et al.
Publicado: (2010)

Emergence of Nanotechnology to Fight HIV Sexual Transmission: The Trip of G2-S16 Polyanionic Carbosilane Dendrimer to Possible Pre-Clinical Trials
por: Relaño-Rodríguez, Ignacio, et al.
Publicado: (2020)

G2-S16 Polyanionic Carbosilane Dendrimer Can Reduce HIV-1 Reservoir Formation by Inhibiting Macrophage Cell to Cell Transmission
por: Relaño-Rodríguez, Ignacio, et al.
Publicado: (2021)

Reactive silver inks for antiviral, repellent medical textiles with ultrasonic bleach washing durability compared to silver nanoparticles
por: Galante, Anthony J., et al.
Publicado: (2022)

Isolation of nuclear envelopes with polyanions
Publicado: (1978)

Clearance of Gram-Negative Bacterial Pathogens from the Ocular Surface by Predatory Bacteria
por: Romanowski, Eric G., et al.
Publicado: (2021)

Intralysosomal accumulation of polyanions. II. Polyanion internalization and its influence on lysosomal pH and membrane fluidity
Publicado: (1982)

Fundamental investigations on the sodium-ion transport properties of mixed polyanion solid-state battery electrolytes
por: Deng, Zeyu, et al.
Publicado: (2022)

Polyanionic Cyclodextrin Induced Supramolecular Nanoparticle
por: Sun, He-Lue, et al.
Publicado: (2016)

The Influence of Polyanions and Polycations on Bacteriophage Activity
por: Musin, Egor V., et al.
Publicado: (2021)

Adenovirus: ocular manifestations
por: Hoffman, Jeremy
Publicado: (2020)

Energy Storage: Polyanion‐Type Electrode Materials for Sodium‐Ion Batteries (Adv. Sci. 3/2017)
por: Ni, Qiao, et al.
Publicado: (2017)

Polyanionic Lattice Modifications Leading to High‐Entropy Sodium Ion Conductors: Mathematical Solution of Accessible Compositions
por: Tietz, Frank, et al.
Publicado: (2020)

Development of vanadium-based polyanion positive electrode active materials for high-voltage sodium-based batteries
por: Shraer, Semyon D., et al.
Publicado: (2022)

The Surface of the Washed Human Erythrocyte as a Polyanion
por: Seaman, G. V. F., et al.
Publicado: (1960)

High-Voltage Polyanion Positive Electrode Materials
por: Yamada, Atsuo
Publicado: (2021)

Author Correction: Fundamental investigations on the sodium-ion transport properties of mixed polyanion solid-state battery electrolytes
por: Deng, Zeyu, et al.
Publicado: (2022)

EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene
por: Grünwald, Geoffrey K, et al.
Publicado: (2013)

Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution
por: Wu, Yuzhou, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_a0c7agm2446qbre1lh4i9u1p7t