Cargando…

Elevated Expression of the RAGE Variant-V in SCLC Mitigates the Effect of Chemotherapeutic Drugs

SIMPLE SUMMARY: Radiomimetic drugs induce extensive genotoxic insults to their target cells. Irreparable DNA damage leaves cells with the choice between a program leading to cell death or senescence, but not DNA repair. Among the challenges of an advanced stage of small cell lung carcinoma (SCLC), t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Madhavan, Bindhu K., Han, Zhe, Singh, Bishal, Bordt, Nico, Kaymak, Serap, Bandapalli, Obul Reddy, Kihm, Lars, Shahzad, Khurrum, Isermann, Berend, Herzig, Stephan, Nawroth, Peter, Kumar, Varun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201239/ https://www.ncbi.nlm.nih.gov/pubmed/34200336 http://dx.doi.org/10.3390/cancers13112843

Ejemplares similares

The importance of nuclear RAGE–Mcm2 axis in diabetes or cancer-associated replication stress
por: Han, Zhe, et al.
Publicado: (2023)

Compromised DNA repair is responsible for diabetes‐associated fibrosis
por: Kumar, Varun, et al.
Publicado: (2020)

Elevated markers of DNA damage and senescence are associated with the progression of albuminuria and restrictive lung disease in patients with type 2 diabetes
por: Varun, Kumar, et al.
Publicado: (2023)

Could Somatostatin Enhance the Outcomes of Chemotherapeutic Treatment in SCLC?
por: Domvri, Kalliopi, et al.
Publicado: (2015)

RAGE Controls Activation and Anti-Inflammatory Signalling of Protein C
por: Braach, Natascha, et al.
Publicado: (2014)

Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair
por: Kumar, Varun, et al.
Publicado: (2017)

Thrombosis and Inflammation—A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C
por: Kohli, Shrey, et al.
Publicado: (2022)

Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy
por: Shahzad, Khurrum, et al.
Publicado: (2016)

Evaluation of Plaque Stability of Advanced Atherosclerotic Lesions in Apo E-Deficient Mice after Treatment with the Oral Factor Xa Inhibitor Rivaroxaban
por: Zhou, Qianxing, et al.
Publicado: (2011)

Clinicopathological Difference and Survival Impact of Patients with c-SCLC and SCLC
por: Zhang, Chenyue, et al.
Publicado: (2021)

Application of single-cell sequencing technologies in pancreatic cancer
por: Mannarapu, Mastan, et al.
Publicado: (2021)

Gene expression profile of CD14(+) blood monocytes following lifestyle-induced weight loss in individuals with metabolic syndrome
por: Biemann, Ronald, et al.
Publicado: (2020)

Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes
por: Humpert, Per M, et al.
Publicado: (2007)

A laser-mediated photo-manipulative toolbox for generation and real-time monitoring of DNA lesions
por: Madhavan, Bindhu K., et al.
Publicado: (2021)

Sonic Hedgehog in SCLC
por: Laukkanen, Mikko O., et al.
Publicado: (2015)

Pathology and Classification of SCLC
por: Raso, Maria Gabriela, et al.
Publicado: (2021)

Procoagulant Extracellular Vesicles Alter Trophoblast Differentiation in Mice by a Thrombo-Inflammatory Mechanism
por: Markmeyer, Paulina, et al.
Publicado: (2021)

Novel Nongenetic Murine Model of Hyperglycemia and Hyperlipidemia-Associated Aggravated Atherosclerosis
por: Gaul, Susanne, et al.
Publicado: (2022)

Opposite effects of tissue inhibitor of metalloproteinases-1 (TIMP-1) over-expression and knockdown on colorectal liver metastases
por: Bandapalli, Obul R, et al.
Publicado: (2012)

Is transformed small cell lung cancer (SCLC) different from de novo SCLC?
por: Park, Cheol-Kyu, et al.
Publicado: (2019)

What Are the Biomarkers for Immunotherapy in SCLC?
por: Longo, Vito, et al.
Publicado: (2021)

Prophylactic cranial irradiation in SCLC
por: Suwinski, Rafal
Publicado: (2021)

Activated protein C reverses epigenetically sustained p66(Shc) expression in plaque-associated macrophages in diabetes
por: Shahzad, Khurrum, et al.
Publicado: (2018)

Lower Plasma Creatinine and Urine Albumin in Individuals at Increased Risk of Type 2 Diabetes with Factor V Leiden Mutation
por: Peter, Andreas, et al.
Publicado: (2014)

Regulation of osteoclast function and bone mass by RAGE
por: Zhou, Zheng, et al.
Publicado: (2006)

Network Topologies Decoding Cervical Cancer
por: Jalan, Sarika, et al.
Publicado: (2015)

Host sphingolipids: Perspective immune adjuvant for controlling SARS-CoV-2 infection for managing COVID-19 disease
por: Prakash, Hridayesh, et al.
Publicado: (2021)

Activated protein C modulates T-cell metabolism and epigenetic FOXP3 induction via α-ketoglutarate
por: Gupta, Dheerendra, et al.
Publicado: (2023)

What's New in SCLC? A Review
por: Oronsky, Bryan, et al.
Publicado: (2017)

Hypercoagulability Impairs Plaque Stability in Diabetes-Induced Atherosclerosis
por: Ambreen, Saira, et al.
Publicado: (2022)

Understanding SCLC heterogeneity and plasticity in cancer metastasis and chemotherapy resistance: Understanding SCLC heterogeneity and plasticity in metastasis and chemoresistance
por: Jin, Yujuan, et al.
Publicado: (2023)

Editorial: Integrated systems genomic approaches for characterizing uncharacterized proteins
por: Valadi, Jayaraman, et al.
Publicado: (2022)

A Germline Mutation in the POT1 Gene Is a Candidate for Familial Non-Medullary Thyroid Cancer
por: Srivastava, Aayushi, et al.
Publicado: (2020)

RAGE signaling sustains inflammation and promotes tumor development
por: Gebhardt, Christoffer, et al.
Publicado: (2008)

Durvalumab: A Review in Extensive-Stage SCLC
por: Al-Salama, Zaina T.
Publicado: (2021)

Arginine Deprivation in SCLC: Mechanisms and Perspectives for Therapy
por: Carpentier, Joséphine, et al.
Publicado: (2022)

Impact of Socioeconomic Factors on Overall Survival in SCLC
por: Roof, Logan, et al.
Publicado: (2022)

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy
por: Shahzad, Khurrum, et al.
Publicado: (2015)

Hypothetical Proteins as Predecessors of Long Non-coding RNAs
por: Malik, Girik, et al.
Publicado: (2020)

Informing patients about their mutation tests: CDKN2A c.256G>A in melanoma as an example
por: Hemminki, Kari, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fgijtfe57f7kj8k4a5ell2l8aq