Cargando…

Disruption of Tfh:B Cell Interactions Prevents Antibody-Mediated Rejection in a Kidney Transplant Model in Rats: Impact of Calcineurin Inhibitor Dose

We aimed to investigate the mechanisms of humoral immune activation in ABMR using a MHC-mismatched rat kidney transplant model. We applied low dose cyclosporine A (loCNI) to allow donor-specific antibody (DSA) formation and rejection and high dose cyclosporine A (hiCNI) for non-rejection. DSA and le...

Descripción completa

Detalles Bibliográficos
Autores principales:	Steines, Louisa, Poth, Helen, Schuster, Antonia, Amann, Kerstin, Banas, Bernhard, Bergler, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201497/ https://www.ncbi.nlm.nih.gov/pubmed/34135891 http://dx.doi.org/10.3389/fimmu.2021.657894

Ejemplares similares

B Cell Activating Factor (BAFF) Is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats
por: Steines, Louisa, et al.
Publicado: (2020)

Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy
por: Kühne, Louisa, et al.
Publicado: (2017)

Dickkopf 3—A New Indicator for the Deterioration of Allograft Function After Kidney Transplantation
por: Schuster, Antonia, et al.
Publicado: (2022)

Safe Long-Term Outcome After Kidney Donation in Older Donors: A Single-Center Experience
por: Schuster, Antonia, et al.
Publicado: (2020)

B-cell activating factor BAFF as a novel alert marker for the immunological risk stratification after kidney transplantation
por: Schuster, Antonia Margarete, et al.
Publicado: (2021)

Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation
por: Bergler, Tobias, et al.
Publicado: (2016)

Follicular Helper T (Tfh) Cells in Autoimmune Diseases and Allograft Rejection
por: Jeon, Yun-Hui, et al.
Publicado: (2016)

The Ratio of CD226 and TIGIT Expression in Tfh and PD-1(+)ICOS(+)Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation
por: Fan, Ji-wen, et al.
Publicado: (2022)

Influence of TGFB1 and CTLA4 polymorphisms on calcineurin inhibitors dose and risk of acute rejection in renal transplantation
por: Bogacz, Anna, et al.
Publicado: (2021)

Regulators of Tfh Cell Differentiation
por: Jogdand, Gajendra M., et al.
Publicado: (2016)

TFH cells in systemic sclerosis
por: Beurier, Pauline, et al.
Publicado: (2021)

Circulating memory T follicular helper subsets, Tfh2 and Tfh17, participate in the pathogenesis of Guillain-Barré syndrome
por: Che, Yuanyuan, et al.
Publicado: (2016)

Functions of Tfh Cells in Common Variable Immunodeficiency
por: Le Saos-Patrinos, Corentin, et al.
Publicado: (2020)

Circulating Tfh1 (cTfh1) cell numbers and PD1 expression are elevated in low-grade B-cell non-Hodgkin’s lymphoma and cTfh gene expression is perturbed in marginal zone lymphoma
por: Byford, Elliot T., et al.
Publicado: (2018)

Anti-CD20 Antibody and Calcineurin Inhibitor Combination Therapy Effectively Suppresses Antibody-Mediated Rejection in Murine Orthotopic Lung Transplantation
por: Matsumoto, Hiroki, et al.
Publicado: (2023)

Calcineurin
por: Creamer, Trevor P.
Publicado: (2020)

Multiplex gene analysis reveals T-cell and antibody-mediated rejection-specific upregulation of complement in renal transplants
por: Vonbrunn, Eva, et al.
Publicado: (2021)

Translational regulation of TFH cell differentiation and autoimmune pathogenesis
por: Patel, Preeyam S., et al.
Publicado: (2022)

Deciphering the spectrum of cutaneous lymphomas expressing TFH markers
por: Donzel, Marie, et al.
Publicado: (2023)

Calcineurin Signaling Mediates Disruption of the Axon Initial Segment Cytoskeleton after Injury
por: Zhao, Yanan, et al.
Publicado: (2020)

Factors influencing the time-intensity curve analysis of contrast-enhanced ultrasound in kidney transplanted patients: Toward a standardized contrast-enhanced ultrasound examination
por: Friedl, Sarah, et al.
Publicado: (2022)

The Efficacy of Rabbit Anti-Thymocyte Globulin for Acute Kidney Transplant Rejection in Patients Using Calcineurin Inhibitor and Mycophenolate Mofetil-Based Immunosuppressive Therapy
por: van der Zwan, Marieke, et al.
Publicado: (2018)

Can Gene Expression Analysis in Zero-Time Biopsies Predict Kidney Transplant Rejection?
por: Vonbrunn, Eva, et al.
Publicado: (2022)

Identification of a urine metabolite constellation characteristic for kidney allograft rejection
por: Banas, Miriam, et al.
Publicado: (2018)

A Prospective Multicenter Trial to Evaluate Urinary Metabolomics for Non-invasive Detection of Renal Allograft Rejection (PARASOL): Study Protocol and Patient Recruitment
por: Banas, Miriam C., et al.
Publicado: (2022)

Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation
por: Quinn, James L., et al.
Publicado: (2018)

Imbalance of Circulating Tfh/Tfr Cells in Patients With Parkinson's Disease
por: Zhao, Xiuzhen, et al.
Publicado: (2020)

Dynamic Regulation of Tfh Selection During the Germinal Center Reaction
por: Merkenschlager, Julia, et al.
Publicado: (2021)

Platelet desialylation and TFH cells–the novel pathway of immune thrombocytopenia
por: Chen, Yuwen, et al.
Publicado: (2021)

Association between Tfh and PGA in children with Henoch–Schönlein purpura
por: Meihua, Miao, et al.
Publicado: (2021)

A Proposal for Early Dosing Regimens in Heart Transplant Patients Receiving Thymoglobulin and Calcineurin Inhibition
por: Barten, Markus J., et al.
Publicado: (2016)

A urinary metabolite constellation to detect acute rejection in kidney allografts
por: Banas, Miriam C., et al.
Publicado: (2019)

Calcineurin-Inhibitor Minimization in Liver Transplant Patients with Calcineurin-Inhibitor-Related Renal Dysfunction: A Meta-Analysis
por: Kong, Yuan, et al.
Publicado: (2011)

Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques
por: Moukambi, Félicien, et al.
Publicado: (2015)

Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients
por: Duan, Ya-qi, et al.
Publicado: (2020)

Regulatory Effect of Sishen Pill on Tfh Cells in Mice With Experimental Colitis
por: Liu, Xue-Ke, et al.
Publicado: (2020)

CD226 and TIGIT Cooperate in the Differentiation and Maturation of Human Tfh Cells
por: Yasutomi, Motoko, et al.
Publicado: (2022)

Cytokine-skewed Tfh cells: functional consequences for B cell help
por: Olatunde, Adesola C., et al.
Publicado: (2021)

Characterization of calcineurin from Cryptococcus humicola and the application of calcineurin in aluminum tolerance
por: Zhang, Lei, et al.
Publicado: (2017)

Sustained low‐dose interleukin‐2 therapy alleviates pathogenic humoral immunity via elevating the Tfr/Tfh ratio in lupus
por: Liang, Kaili, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cbidsupocrhj1ui19c9m7h7b0a