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Increased peak detection accuracy in over-dispersed ChIP-seq data with supervised segmentation models
BACKGROUND: Histone modification constitutes a basic mechanism for the genetic regulation of gene expression. In early 2000s, a powerful technique has emerged that couples chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq). This technique provides a direct survey of the DNA reg...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201703/ https://www.ncbi.nlm.nih.gov/pubmed/34126932 http://dx.doi.org/10.1186/s12859-021-04221-5 |