Protective Effects of Sacubitril/Valsartan on Cardiac Fibrosis and Function in Rats With Experimental Myocardial Infarction Involves Inhibition of Collagen Synthesis by Myocardial Fibroblasts Through Downregulating TGF-β1/Smads Pathway

Objectives: To investigate the effect and mechanism of sacubitril/valsartan on myocardial fibrosis in rats following experimental myocardial infarction and in TGF-β1-treated myocardial fibroblasts. Methods: Male Sprague-Dawley (SD) rats were subjected to coronary artery ligation to establish myocard...

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Detalles Bibliográficos
Autores principales: Wu, Meifang, Guo, Yanguang, Wu, Ying, Xu, Kaizu, Lin, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201773/
https://www.ncbi.nlm.nih.gov/pubmed/34135764
http://dx.doi.org/10.3389/fphar.2021.696472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201773/
https://www.ncbi.nlm.nih.gov/pubmed/34135764
http://dx.doi.org/10.3389/fphar.2021.696472

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