Memantine ameliorates cognitive deficit in AD mice via enhancement of entorhinal–CA1 projection

BACKGROUND: Memantine, a low- to moderate-affinity uncompetitive N-methyl-D-aspartate receptor antagonist, has been shown to improve cognitive functions in animal models of Alzheimer’s disease (AD). Here we treated APP/PS1 AD mice with a therapeutic dose of memantine (20 mg/kg/day) and examined its...

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Detalles Bibliográficos
Autores principales: Li, Peng, Xu, Jin, Gu, Huanhuan, Peng, Hua, Yin, You, Zhuang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201811/
https://www.ncbi.nlm.nih.gov/pubmed/34120588
http://dx.doi.org/10.1186/s12868-021-00647-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201811/
https://www.ncbi.nlm.nih.gov/pubmed/34120588
http://dx.doi.org/10.1186/s12868-021-00647-y

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