Cargando…

Surgical and functional outcomes and survival following Colon Cancer surgery in the aged: a study protocol for a prospective, observational multicentre study

BACKGROUND: The number of colorectal cancer patients increases with age. The decision to go through major surgery can be challenging for the aged patient and the surgeon because of the heterogeneity within the older population. Differences in preoperative physical and cognitive status can affect pos...

Descripción completa

Detalles Bibliográficos
Autores principales: Niemeläinen, Susanna, Huhtala, Heini, Ehrlich, Anu, Kössi, Jyrki, Jämsen, Esa, Hyöty, Marja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201898/
https://www.ncbi.nlm.nih.gov/pubmed/34126949
http://dx.doi.org/10.1186/s12885-021-08454-8
_version_ 1783707885424869376
author Niemeläinen, Susanna
Huhtala, Heini
Ehrlich, Anu
Kössi, Jyrki
Jämsen, Esa
Hyöty, Marja
author_facet Niemeläinen, Susanna
Huhtala, Heini
Ehrlich, Anu
Kössi, Jyrki
Jämsen, Esa
Hyöty, Marja
author_sort Niemeläinen, Susanna
collection PubMed
description BACKGROUND: The number of colorectal cancer patients increases with age. The decision to go through major surgery can be challenging for the aged patient and the surgeon because of the heterogeneity within the older population. Differences in preoperative physical and cognitive status can affect postoperative outcomes and functional recovery, and impact on patients’ quality of life. METHODS / DESIGN: A prospective, observational, multicentre study including nine hospitals to analyse the impact of colon cancer surgery on functional ability, short-term outcomes (complications and mortality), and their predictors in patients aged ≥80 years. The catchment area of the study hospitals is 3.88 million people, representing 70% of the population of Finland. The data will be gathered from patient baseline characteristics, surgical interventional data, and pre- and postoperative patient-questionnaires, to an electronic database (REDCap) especially dedicated to the study. DISCUSSION: This multicentre study provides information about colon cancer surgery’s operative and functional outcomes on older patients. A further aim is to find prognostic factors which could help to predict adverse outcomes of surgery. TRIAL REGISTRATION: ClinicalTrials.gov (NCT03904121). Registered on 1 April 2019. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08454-8.
format Online
Article
Text
id pubmed-8201898
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-82018982021-06-16 Surgical and functional outcomes and survival following Colon Cancer surgery in the aged: a study protocol for a prospective, observational multicentre study Niemeläinen, Susanna Huhtala, Heini Ehrlich, Anu Kössi, Jyrki Jämsen, Esa Hyöty, Marja BMC Cancer Study Protocol BACKGROUND: The number of colorectal cancer patients increases with age. The decision to go through major surgery can be challenging for the aged patient and the surgeon because of the heterogeneity within the older population. Differences in preoperative physical and cognitive status can affect postoperative outcomes and functional recovery, and impact on patients’ quality of life. METHODS / DESIGN: A prospective, observational, multicentre study including nine hospitals to analyse the impact of colon cancer surgery on functional ability, short-term outcomes (complications and mortality), and their predictors in patients aged ≥80 years. The catchment area of the study hospitals is 3.88 million people, representing 70% of the population of Finland. The data will be gathered from patient baseline characteristics, surgical interventional data, and pre- and postoperative patient-questionnaires, to an electronic database (REDCap) especially dedicated to the study. DISCUSSION: This multicentre study provides information about colon cancer surgery’s operative and functional outcomes on older patients. A further aim is to find prognostic factors which could help to predict adverse outcomes of surgery. TRIAL REGISTRATION: ClinicalTrials.gov (NCT03904121). Registered on 1 April 2019. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08454-8. BioMed Central 2021-06-14 /pmc/articles/PMC8201898/ /pubmed/34126949 http://dx.doi.org/10.1186/s12885-021-08454-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Study Protocol
Niemeläinen, Susanna
Huhtala, Heini
Ehrlich, Anu
Kössi, Jyrki
Jämsen, Esa
Hyöty, Marja
Surgical and functional outcomes and survival following Colon Cancer surgery in the aged: a study protocol for a prospective, observational multicentre study
title Surgical and functional outcomes and survival following Colon Cancer surgery in the aged: a study protocol for a prospective, observational multicentre study
title_full Surgical and functional outcomes and survival following Colon Cancer surgery in the aged: a study protocol for a prospective, observational multicentre study
title_fullStr Surgical and functional outcomes and survival following Colon Cancer surgery in the aged: a study protocol for a prospective, observational multicentre study
title_full_unstemmed Surgical and functional outcomes and survival following Colon Cancer surgery in the aged: a study protocol for a prospective, observational multicentre study
title_short Surgical and functional outcomes and survival following Colon Cancer surgery in the aged: a study protocol for a prospective, observational multicentre study
title_sort surgical and functional outcomes and survival following colon cancer surgery in the aged: a study protocol for a prospective, observational multicentre study
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201898/
https://www.ncbi.nlm.nih.gov/pubmed/34126949
http://dx.doi.org/10.1186/s12885-021-08454-8
work_keys_str_mv AT niemelainensusanna surgicalandfunctionaloutcomesandsurvivalfollowingcoloncancersurgeryintheagedastudyprotocolforaprospectiveobservationalmulticentrestudy
AT huhtalaheini surgicalandfunctionaloutcomesandsurvivalfollowingcoloncancersurgeryintheagedastudyprotocolforaprospectiveobservationalmulticentrestudy
AT ehrlichanu surgicalandfunctionaloutcomesandsurvivalfollowingcoloncancersurgeryintheagedastudyprotocolforaprospectiveobservationalmulticentrestudy
AT kossijyrki surgicalandfunctionaloutcomesandsurvivalfollowingcoloncancersurgeryintheagedastudyprotocolforaprospectiveobservationalmulticentrestudy
AT jamsenesa surgicalandfunctionaloutcomesandsurvivalfollowingcoloncancersurgeryintheagedastudyprotocolforaprospectiveobservationalmulticentrestudy
AT hyotymarja surgicalandfunctionaloutcomesandsurvivalfollowingcoloncancersurgeryintheagedastudyprotocolforaprospectiveobservationalmulticentrestudy