Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer

Tumors frequently express unmutated self-tumor–associated antigens (self-TAAs). However, trial results using self-TAAs as vaccine targets against cancer are mixed, often attributed to deletion of T cells with high-affinity receptors (TCRs) for self-TAAs during T cell development. Mutating these weak...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Pengcheng, Jordan, Kimberly R., Buhrman, Jonathan D., Lei, Jun, Deng, Hexiang, Marrack, Philippa, Dai, Shaodong, Kappler, John W., Slansky, Jill E., Yin, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201969/
https://www.ncbi.nlm.nih.gov/pubmed/34074778
http://dx.doi.org/10.1073/pnas.2100588118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201969/
https://www.ncbi.nlm.nih.gov/pubmed/34074778
http://dx.doi.org/10.1073/pnas.2100588118

Ejemplares similares