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Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer

Tumors frequently express unmutated self-tumor–associated antigens (self-TAAs). However, trial results using self-TAAs as vaccine targets against cancer are mixed, often attributed to deletion of T cells with high-affinity receptors (TCRs) for self-TAAs during T cell development. Mutating these weak...

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Detalles Bibliográficos
Autores principales:	Wei, Pengcheng, Jordan, Kimberly R., Buhrman, Jonathan D., Lei, Jun, Deng, Hexiang, Marrack, Philippa, Dai, Shaodong, Kappler, John W., Slansky, Jill E., Yin, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201969/ https://www.ncbi.nlm.nih.gov/pubmed/34074778 http://dx.doi.org/10.1073/pnas.2100588118

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