NUPR1 is a novel potential biomarker and confers resistance to sorafenib in clear cell renal cell carcinoma by increasing stemness and targeting the PTEN/AKT/mTOR pathway

Background: Sorafenib can improve the survival of metastatic clear cell renal cell carcinoma (ccRCC) patients. However, its benefits are modest, as patients eventually become resistant, and the mechanisms remain elusive. NUPR1, a stress-induced protein, has been reported in malignancies and function...

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Detalles Bibliográficos
Autores principales: He, Wei, Cheng, Fajuan, Zheng, Bin, Wang, Jianwei, Zhao, Guiting, Yao, Zhongshun, Zhang, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202846/
https://www.ncbi.nlm.nih.gov/pubmed/34030133
http://dx.doi.org/10.18632/aging.203012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202846/
https://www.ncbi.nlm.nih.gov/pubmed/34030133
http://dx.doi.org/10.18632/aging.203012

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