Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism

BACKGROUND/AIM: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer cells (PBCCs). MATERIALS AND METHODS: PBCCs were treated with two doses of metformin (0 mM, 25 mM). Proliferation was deter...

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Detalles Bibliográficos
Autores principales: YENMİŞ, Güven, Beşli, Nail, YAPRAK SARAÇ, Elif, HOCAOĞLU EMRE, Fatma Sinem, ŞENOL, Kazım, KANIGÜR SULTUYBEK, Gönül
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203121/
https://www.ncbi.nlm.nih.gov/pubmed/33350292
http://dx.doi.org/10.3906/sag-1908-112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203121/
https://www.ncbi.nlm.nih.gov/pubmed/33350292
http://dx.doi.org/10.3906/sag-1908-112

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