Multiple Administrations of Itraconazole Increase Plasma Exposure to Pyrotinib in Chinese Healthy Adults

PURPOSE: Pyrotinib, an irreversible human epidermal growth factor receptor 2 (HER2), is a epidermal growth factor receptor double-target tyrosine kinase inhibitor used for treating HER2-positive breast cancer. This study aimed to evaluate the impact of the strong CYP3A4 inhibitor itraconazole on the...

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Detalles Bibliográficos
Autores principales: Liu, Yueyue, Zhang, Qian, Lu, Chao, Hu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203185/
https://www.ncbi.nlm.nih.gov/pubmed/34140765
http://dx.doi.org/10.2147/DDDT.S312310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203185/
https://www.ncbi.nlm.nih.gov/pubmed/34140765
http://dx.doi.org/10.2147/DDDT.S312310

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