A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects

NaCT (SLC13A5) is a Na(+)-coupled transporter for citrate, which is expressed in the liver, brain, testes, and bone. It is the mammalian homolog of Drosophila INDY, a cation-independent transporter for citrate, whose partial loss extends lifespan in the organism. In humans, loss-of-function mutation...

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Detalles Bibliográficos
Autores principales: Jaramillo-Martinez, Valeria, Ganapathy, Vadivel, Urbatsch, Ina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203205/
https://www.ncbi.nlm.nih.gov/pubmed/34101804
http://dx.doi.org/10.1042/BCJ20210211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203205/
https://www.ncbi.nlm.nih.gov/pubmed/34101804
http://dx.doi.org/10.1042/BCJ20210211

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