Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence

ARID1A is one of the most frequently mutated epigenetic regulators in a wide spectrum of cancers. Recent studies have shown that ARID1A deficiency induces global changes in the epigenetic landscape of enhancers and promoters. These broad and complex effects make it challenging to identify the drivin...

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Detalles Bibliográficos
Autores principales: Liu, Shou, Cao, Wenjian, Niu, Yichi, Luo, Jiayi, Zhao, Yanhua, Hu, Zhiying, Zong, Chenghang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203294/
https://www.ncbi.nlm.nih.gov/pubmed/33983114
http://dx.doi.org/10.7554/eLife.64204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203294/
https://www.ncbi.nlm.nih.gov/pubmed/33983114
http://dx.doi.org/10.7554/eLife.64204

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