A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8(+) T cell tolerance

Naturally occurring cases of monogenic type 1 diabetes (T1D) help establish direct mechanisms driving this complex autoimmune disease. A recently identified de novo germline gain-of-function (GOF) mutation in the transcriptional regulator STAT3 was found to cause neonatal T1D. We engineered a novel...

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Detalles Bibliográficos
Autores principales: Warshauer, Jeremy T., Belk, Julia A., Chan, Alice Y., Wang, Jiaxi, Gupta, Alexander R., Shi, Quanming, Skartsis, Nikolaos, Peng, Yani, Phipps, Jonah D., Acenas, Dante, Smith, Jennifer A., Tamaki, Stanley J., Tang, Qizhi, Gardner, James M., Satpathy, Ansuman T., Anderson, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203485/
https://www.ncbi.nlm.nih.gov/pubmed/34115115
http://dx.doi.org/10.1084/jem.20210759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203485/
https://www.ncbi.nlm.nih.gov/pubmed/34115115
http://dx.doi.org/10.1084/jem.20210759

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