Engineering the protein dynamics of an ancestral luciferase

Protein dynamics are often invoked in explanations of enzyme catalysis, but their design has proven elusive. Here we track the role of dynamics in evolution, starting from the evolvable and thermostable ancestral protein Anc(HLD-RLuc) which catalyses both dehalogenase and luciferase reactions. Inser...

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Detalles Bibliográficos
Autores principales: Schenkmayerova, Andrea, Pinto, Gaspar P., Toul, Martin, Marek, Martin, Hernychova, Lenka, Planas-Iglesias, Joan, Daniel Liskova, Veronika, Pluskal, Daniel, Vasina, Michal, Emond, Stephane, Dörr, Mark, Chaloupkova, Radka, Bednar, David, Prokop, Zbynek, Hollfelder, Florian, Bornscheuer, Uwe T., Damborsky, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203615/
https://www.ncbi.nlm.nih.gov/pubmed/34127663
http://dx.doi.org/10.1038/s41467-021-23450-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203615/
https://www.ncbi.nlm.nih.gov/pubmed/34127663
http://dx.doi.org/10.1038/s41467-021-23450-z

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