Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG

A single intradermal vaccination with an antibiotic-less version of BCGΔBCG1419c given to guinea pigs conferred a significant improvement in outcome following a low dose aerosol exposure to M. tuberculosis compared to that provided by a single dose of BCG Pasteur. BCGΔBCG1419c was more attenuated th...

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Detalles Bibliográficos
Autores principales: Aceves-Sánchez, Michel de Jesús, Flores-Valdez, Mario Alberto, Pedroza-Roldán, César, Creissen, Elizabeth, Izzo, Linda, Silva-Angulo, Fabiola, Dawson, Clinton, Izzo, Angelo, Bielefeldt-Ohmann, Helle, Segura-Cerda, Cristian Alfredo, López-Romero, Wendy, Bravo-Madrigal, Jorge, Barrios-Payán, Jorge Alberto, de la Cruz, Miguel Ángel, Ares, Miguel, Jorge-Espinoza, María Guadalupe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203684/
https://www.ncbi.nlm.nih.gov/pubmed/34127755
http://dx.doi.org/10.1038/s41598-021-91993-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203684/
https://www.ncbi.nlm.nih.gov/pubmed/34127755
http://dx.doi.org/10.1038/s41598-021-91993-8

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