Cargando…

The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice

Genetic crosses are most powerful for linkage analysis when progeny numbers are high, parental alleles segregate evenly and numbers of inbred progeny are minimized. We previously developed a novel genetic crossing platform for the human malaria parasite Plasmodium falciparum, an obligately sexual, h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Button-Simons, Katrina A., Kumar, Sudhir, Carmago, Nelly, Haile, Meseret T., Jett, Catherine, Checkley, Lisa A., Kennedy, Spencer Y., Pinapati, Richard S., Shoue, Douglas A., McDew-White, Marina, Li, Xue, Nosten, François H., Kappe, Stefan H., Anderson, Timothy J. C., Romero-Severson, Jeanne, Ferdig, Michael T., Emrich, Scott J., Vaughan, Ashley M., Cheeseman, Ian H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203791/ https://www.ncbi.nlm.nih.gov/pubmed/34127785 http://dx.doi.org/10.1038/s42003-021-02210-1

Ejemplares similares

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle
por: Li, Xue, et al.
Publicado: (2019)

A Malaria Parasite Cross Reveals Genetic Determinants of Plasmodium falciparum Growth in Different Culture Media
por: Kumar, Sudhir, et al.
Publicado: (2022)

Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice
por: Brenneman, Katelyn Vendrely, et al.
Publicado: (2022)

Plasmodium falciparum genetic crosses in a humanized mouse model
por: Vaughan, Ashley M., et al.
Publicado: (2015)

The extended recovery ring-stage survival assay provides a superior association with patient clearance half-life and increases throughput
por: Davis, Sage Z., et al.
Publicado: (2020)

Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite
por: Siwo, Geoffrey H, et al.
Publicado: (2015)

Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1
por: Amambua-Ngwa, Alfred, et al.
Publicado: (2023)

Pairwise growth competitions identify relative fitness relationships among artemisinin resistant Plasmodium falciparum field isolates
por: Tirrell, Abigail R., et al.
Publicado: (2019)

A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance
por: Kane, John, et al.
Publicado: (2023)

An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum
por: Siwo, Geoffrey H., et al.
Publicado: (2015)

Pooled Sequencing and Rare Variant Association Tests for Identifying the Determinants of Emerging Drug Resistance in Malaria Parasites
por: Cheeseman, Ian H., et al.
Publicado: (2015)

Simultaneous genome-wide gene expression and transcript isoform profiling in the human malaria parasite
por: Turnbull, Lindsey B., et al.
Publicado: (2017)

Cyclical regression covariates remove the major confounding effect of cyclical developmental gene expression with strain-specific drug response in the malaria parasite Plasmodium falciparum
por: Foster, Gabriel J., et al.
Publicado: (2022)

Prediction of fine-tuned promoter activity from DNA sequence
por: Siwo, Geoffrey, et al.
Publicado: (2016)

A Putative Plasmodium RNA-Binding Protein Plays a Critical Role in Female Gamete Fertility and Parasite Transmission to the Mosquito Vector
por: Kumar, Sudhir, et al.
Publicado: (2022)

A Plasmodium falciparum ATP-binding cassette transporter is essential for liver stage entry into schizogony
por: Goswami, Debashree, et al.
Publicado: (2022)

PfSRPK1 Regulates Asexual Blood Stage Schizogony and Is Essential for Male Gamete Formation
por: Kumar, Sudhir, et al.
Publicado: (2022)

PfARID Regulates P. falciparum Malaria Parasite Male Gametogenesis and Female Fertility and Is Critical for Parasite Transmission to the Mosquito Vector
por: Kumar, Sudhir, et al.
Publicado: (2022)

Population Parameters Underlying an Ongoing Soft Sweep in Southeast Asian Malaria Parasites
por: Anderson, Timothy J.C., et al.
Publicado: (2017)

Mode and Tempo of Microsatellite Length Change in a Malaria Parasite Mutation Accumulation Experiment
por: McDew-White, Marina, et al.
Publicado: (2019)

Malaria parasites utilize two essential plasma membrane fusogens for gamete fertilization
por: Kumar, Sudhir, et al.
Publicado: (2022)

Fitness Costs and the Rapid Spread of kelch13-C580Y Substitutions Conferring Artemisinin Resistance
por: Nair, Shalini, et al.
Publicado: (2018)

Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum
por: Gibbons, Justin, et al.
Publicado: (2018)

Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance
por: Cerqueira, Gustavo C., et al.
Publicado: (2017)

Hackathons as a means of accelerating scientific discoveries and knowledge transfer
por: Ghouila, Amel, et al.
Publicado: (2018)

Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector
por: Kumar, Sudhir, et al.
Publicado: (2021)

Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery
por: Pradhan, Anupam, et al.
Publicado: (2015)

Haplotype and minimum-chimerism consensus determination using short sequence data
por: O'Neil, Shawn T, et al.
Publicado: (2012)

Plasmodium microtubule-binding protein EB1 is critical for partitioning of nuclei in male gametogenesis
por: Mauer, Sydney, et al.
Publicado: (2023)

Artemisinin-Resistant Plasmodium falciparum K13 Mutant Alleles, Thailand–Myanmar Border
por: Boullé, Mikael, et al.
Publicado: (2016)

SIV Infection Regulates Compartmentalization of Circulating Blood Plasma miRNAs within Extracellular Vesicles (EVs) and Extracellular Condensates (ECs) and Decreases EV-Associated miRNA-128
por: Kopcho, Steven, et al.
Publicado: (2023)

Alterations in Abundance and Compartmentalization of miRNAs in Blood Plasma Extracellular Vesicles and Extracellular Condensates during HIV/SIV Infection and Its Modulation by Antiretroviral Therapy (ART) and Delta-9-Tetrahydrocannabinol (Δ(9)-THC)
por: Kopcho, Steven, et al.
Publicado: (2023)

Genetic architecture of transmission stage production and virulence in schistosome parasites
por: Le Clec’h, Winka, et al.
Publicado: (2021)

Cannabinoids modulate the microbiota–gut–brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels
por: McDew-White, Marina, et al.
Publicado: (2023)

The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
por: Zhang, Min, et al.
Publicado: (2021)

PfHMGB2 has a role in malaria parasite mosquito infection
por: Kumar, Sudhir, et al.
Publicado: (2022)

Transformation of Sporozoites into Early Exoerythrocytic Malaria Parasites Does Not Require Host Cells
por: Kaiser, Karine, et al.
Publicado: (2003)

Striking differences in virulence, transmission and sporocyst growth dynamics between two schistosome populations
por: Le Clecʼh, Winka, et al.
Publicado: (2019)

A statistical approach to finding overlooked genetic associations
por: Rider, Andrew K, et al.
Publicado: (2010)

Antigenic diversity in malaria parasites is maintained on extrachromosomal DNA
por: Ebel, Emily R., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j11dv1osrroph58a5qrosfgid5