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Synaptopathy Mechanisms in ALS Caused by C9orf72 Repeat Expansion
Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disease caused by degeneration of motor neurons (MNs). ALS pathogenic features include accumulation of misfolded proteins, glutamate excitotoxicity, mitochondrial dysfunction at distal axon terminals, and neuronal cytoskeleton change...
Autores principales: | Nishimura, Agnes L., Arias, Natalia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203826/ https://www.ncbi.nlm.nih.gov/pubmed/34140881 http://dx.doi.org/10.3389/fncel.2021.660693 |
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