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Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population
Integrin regulation by Rap1 is indispensable for lymphocyte recirculation. In mice having B-cell-specific Rap1a/b double knockouts (DKO), the number of B cells in lymph nodes decreased to approximately 4% of that of control mice, and B cells were present in the spleen and blood. Upon the immunizatio...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203927/ https://www.ncbi.nlm.nih.gov/pubmed/34140948 http://dx.doi.org/10.3389/fimmu.2021.624419 |