Discovery of SARS-CoV-2 main protease inhibitors using a synthesis-directed de novo design model

The SARS-CoV-2 main viral protease (M(pro)) is an attractive target for antivirals given its distinctiveness from host proteases, essentiality in the viral life cycle and conservation across coronaviridae. We launched the COVID Moonshot initiative to rapidly develop patent-free antivirals with open...

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Detalles Bibliográficos
Autores principales: Morris, Aaron, McCorkindale, William, Consortium, The COVID Moonshot, Drayman, Nir, Chodera, John D., Tay, Savaş, London, Nir, Lee, Alpha A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204246/
https://www.ncbi.nlm.nih.gov/pubmed/34008627
http://dx.doi.org/10.1039/d1cc00050k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204246/
https://www.ncbi.nlm.nih.gov/pubmed/34008627
http://dx.doi.org/10.1039/d1cc00050k

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