Mechanism of ArcLight derived GEVIs involves electrostatic interactions that can affect proton wires

The genetically encoded voltage indicators ArcLight and its derivatives mediate voltage-dependent optical signals by intermolecular, electrostatic interactions between neighboring fluorescent proteins (FPs). A random mutagenesis event placed a negative charge on the exterior of the FP, resulting in...

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Detalles Bibliográficos
Autores principales: Kang, Bok Eum, Leong, Lee Min, Kim, Yoonkyung, Miyazaki, Kenichi, Ross, William N., Baker, Bradley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204334/
https://www.ncbi.nlm.nih.gov/pubmed/33744263
http://dx.doi.org/10.1016/j.bpj.2021.03.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204334/
https://www.ncbi.nlm.nih.gov/pubmed/33744263
http://dx.doi.org/10.1016/j.bpj.2021.03.009

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