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Mechanism of ArcLight derived GEVIs involves electrostatic interactions that can affect proton wires
The genetically encoded voltage indicators ArcLight and its derivatives mediate voltage-dependent optical signals by intermolecular, electrostatic interactions between neighboring fluorescent proteins (FPs). A random mutagenesis event placed a negative charge on the exterior of the FP, resulting in...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204334/ https://www.ncbi.nlm.nih.gov/pubmed/33744263 http://dx.doi.org/10.1016/j.bpj.2021.03.009 |