The structural basis of Akt PH domain interaction with calmodulin

Akt plays a key role in the Ras/PI3K/Akt/mTOR signaling pathway. In breast cancer, Akt translocation to the plasma membrane is enabled by the interaction of its pleckstrin homology domain (PHD) with calmodulin (CaM). At the membrane, the conformational change promoted by PIP(3) releases CaM and faci...

Descripción completa

Detalles Bibliográficos
Autores principales: Weako, Jackson, Jang, Hyunbum, Keskin, Ozlem, Nussinov, Ruth, Gursoy, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204387/
https://www.ncbi.nlm.nih.gov/pubmed/33775637
http://dx.doi.org/10.1016/j.bpj.2021.03.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204387/
https://www.ncbi.nlm.nih.gov/pubmed/33775637
http://dx.doi.org/10.1016/j.bpj.2021.03.018

Ejemplares similares