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The structural basis of Akt PH domain interaction with calmodulin
Akt plays a key role in the Ras/PI3K/Akt/mTOR signaling pathway. In breast cancer, Akt translocation to the plasma membrane is enabled by the interaction of its pleckstrin homology domain (PHD) with calmodulin (CaM). At the membrane, the conformational change promoted by PIP(3) releases CaM and faci...
Autores principales: | Weako, Jackson, Jang, Hyunbum, Keskin, Ozlem, Nussinov, Ruth, Gursoy, Attila |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204387/ https://www.ncbi.nlm.nih.gov/pubmed/33775637 http://dx.doi.org/10.1016/j.bpj.2021.03.018 |
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