Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein

CHK1 is a protein kinase that functions downstream of activated ATR to phosphorylate multiple targets as part of intra-S and G2/M DNA damage checkpoints. Its role in allowing cells to survive replicative stress has made it an important target for anti-cancer drug discovery. Activation of CHK1 by ATR...

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Detalles Bibliográficos
Autores principales: Day, Matthew, Parry-Morris, Sarah, Houghton-Gisby, Jack, Oliver, Antony W., Pearl, Laurence H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204404/
https://www.ncbi.nlm.nih.gov/pubmed/33789090
http://dx.doi.org/10.1016/j.str.2021.03.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204404/
https://www.ncbi.nlm.nih.gov/pubmed/33789090
http://dx.doi.org/10.1016/j.str.2021.03.007

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