Cargando…
Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein
CHK1 is a protein kinase that functions downstream of activated ATR to phosphorylate multiple targets as part of intra-S and G2/M DNA damage checkpoints. Its role in allowing cells to survive replicative stress has made it an important target for anti-cancer drug discovery. Activation of CHK1 by ATR...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204404/ https://www.ncbi.nlm.nih.gov/pubmed/33789090 http://dx.doi.org/10.1016/j.str.2021.03.007 |