Parkinson’s disease–associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy

BACKGROUND: Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease (PD), and several genes linked to familial PD, including PINK1 (encoding PTEN-induced putative kinase 1 [PINK1]) and PARK2 (encoding the E3 ubiquitin ligase Parkin), are directly involved in proce...

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Detalles Bibliográficos
Autores principales: Ma, Kai Yu, Fokkens, Michiel R., Reggiori, Fulvio, Mari, Muriel, Verbeek, Dineke S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204421/
https://www.ncbi.nlm.nih.gov/pubmed/34127073
http://dx.doi.org/10.1186/s40035-021-00243-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204421/
https://www.ncbi.nlm.nih.gov/pubmed/34127073
http://dx.doi.org/10.1186/s40035-021-00243-4

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