Cargando…

Structural basis of TRAPPIII‐mediated Rab1 activation

The GTPase Rab1 is a master regulator of the early secretory pathway and is critical for autophagy. Rab1 activation is controlled by its guanine nucleotide exchange factor, the multisubunit TRAPPIII complex. Here, we report the 3.7 Å cryo‐EM structure of the Saccharomyces cerevisiae TRAPPIII complex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Joiner, Aaron MN, Phillips, Ben P, Yugandhar, Kumar, Sanford, Ethan J, Smolka, Marcus B, Yu, Haiyuan, Miller, Elizabeth A, Fromme, J Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204860/ https://www.ncbi.nlm.nih.gov/pubmed/34018207 http://dx.doi.org/10.15252/embj.2020107607

Ejemplares similares

The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway
por: Thomas, Laura L., et al.
Publicado: (2018)

Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab1
por: Galindo, Antonio, et al.
Publicado: (2021)

Mammalian TRAPPIII Complex positively modulates the recruitment of Sec13/31 onto COPII vesicles
por: Zhao, Shan, et al.
Publicado: (2017)

The P4‐ATPase Drs2 interacts with and stabilizes the multisubunit tethering complex TRAPPIII in yeast
por: Pazos, Irene, et al.
Publicado: (2023)

Maximized quantitative phosphoproteomics allows high confidence dissection of the DNA damage signaling network
por: Faca, Vitor Marcel, et al.
Publicado: (2020)

Molecular Basis for Rab Prenylation
por: Alory, Christelle, et al.
Publicado: (2000)

Inferring Protein-Protein Interaction Networks From Mass Spectrometry-Based Proteomic Approaches: A Mini-Review
por: Yugandhar, Kumar, et al.
Publicado: (2019)

Arf1 orchestrates Rab GTPase conversion at the trans-Golgi network
por: Thomas, Laura L., et al.
Publicado: (2021)

GTPase cross talk regulates TRAPPII activation of Rab11 homologues during vesicle biogenesis
por: Thomas, Laura L., et al.
Publicado: (2016)

Structure of a TRAPPII-Rab11 activation intermediate reveals GTPase substrate selection mechanisms
por: Bagde, Saket R., et al.
Publicado: (2022)

Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11
por: Thibodeau, Matthew C., et al.
Publicado: (2022)

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
por: Tremel, Shirley, et al.
Publicado: (2021)

Handcuffing intrinsically disordered regions in Mlh1–Pms1 disrupts mismatch repair
por: Furman, Christopher M, et al.
Publicado: (2021)

Structural basis for activation of Arf1 at the Golgi complex
por: Muccini, Arnold J., et al.
Publicado: (2022)

Structure-based validation can drastically under-estimate error rate in proteome-wide cross-linking mass spectrometry studies
por: Yugandhar, Kumar, et al.
Publicado: (2020)

Structural Basis of Membrane Trafficking by Rab Family Small G Protein
por: Park, Hyun Ho
Publicado: (2013)

Structural basis for autophagy inhibition by the human Rubicon–Rab7 complex
por: Bhargava, Hersh K., et al.
Publicado: (2020)

Structural basis for the specificity of PPM1H phosphatase for Rab GTPases
por: Waschbüsch, Dieter, et al.
Publicado: (2021)

Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors
por: Ying, Guoxin, et al.
Publicado: (2016)

Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling
por: Lanz, Michael Charles, et al.
Publicado: (2018)

Mec1-independent activation of the Rad53 checkpoint kinase revealed by quantitative analysis of protein localization dynamics
por: Ho, Brandon, et al.
Publicado: (2023)

Rab-mediated vesicle trafficking in cancer
por: Tzeng, Hong-Tai, et al.
Publicado: (2016)

Activity of a ubiquitin ligase adaptor is regulated by disordered insertions in its arrestin domain
por: Baile, Matthew G., et al.
Publicado: (2019)

Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD
por: Chen, Yang, et al.
Publicado: (2013)

Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5
por: Goto-Ito, Sakurako, et al.
Publicado: (2019)

Glucosylation by the Legionella Effector SetA Promotes the Nuclear Localization of the Transcription Factor TFEB
por: Beck, Wendy H.J., et al.
Publicado: (2020)

TBC-2 Regulates RAB-5/RAB-7-mediated Endosomal Trafficking in Caenorhabditis elegans
por: Chotard, Laëtitia, et al.
Publicado: (2010)

In Vivo Visual Screen for Dopaminergic Rab ↔ LRRK2-G2019S Interactions in Drosophila Discriminates Rab10 from Rab3
por: Petridi, Stavroula, et al.
Publicado: (2020)

Correction: Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD
por: Chen, Yang, et al.
Publicado: (2013)

Structural basis of human ORP1-Rab7 interaction for the late-endosome and lysosome targeting
por: Tong, Junsen, et al.
Publicado: (2019)

Structural basis of human PDZD8–Rab7 interaction for the ER-late endosome tethering
por: Khan, Haider, et al.
Publicado: (2021)

Endosomal Rab cycles regulate Parkin-mediated mitophagy
por: Yamano, Koji, et al.
Publicado: (2018)

Novel interaction of Rab13 and Rab8 with endospanins()
por: Hirvonen, Mirkka J., et al.
Publicado: (2013)

Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain
por: Huang, Liguo, et al.
Publicado: (2019)

Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations
por: Rivero-Ríos, Pilar, et al.
Publicado: (2020)

The identification of protein domains that mediate functional interactions between Rab-GTPases and RabGAPs using 3D protein modeling
por: Davie, Jeremiah J, et al.
Publicado: (2017)

A novel membrane targeting domain mediates the endosomal or Golgi localization specificity of small GTPases Rab22 and Rab31
por: Banworth, Marcellus J., et al.
Publicado: (2022)

Rab GEFs emerge from their DENN
por: Short, Ben
Publicado: (2010)

Rab35 drives exosome secretion
por: Short, Ben
Publicado: (2010)

GEFs help Rabs find their target
por: Short, Ben
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_kphrcpofvt2og44j3ndj25hgbf