Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs

Combination therapy is a common approach for clinical treatment of type 2 diabetes mellitus, especially for patients with poor monotherapy. Meta-analysis suggested that omarigliptin, a long-acting DPP-4 inhibitor, combined with pioglitazone might improve the side effects of pioglitazone. However, li...

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Detalles Bibliográficos
Autores principales: Wang, Lin, Wang, Jiaxi, Lin, Chao, Wang, Furong, Li, Xiangping, Liu, Wanhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205603/
https://www.ncbi.nlm.nih.gov/pubmed/34211797
http://dx.doi.org/10.1155/2021/6693366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205603/
https://www.ncbi.nlm.nih.gov/pubmed/34211797
http://dx.doi.org/10.1155/2021/6693366

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